Npgrj_NN_1543 1298..1300

نویسندگان

  • Adam Gazzaley
  • Jeffrey W Cooney
  • Jesse Rissman
چکیده

In this study, we assess the impact of normal aging on top-down modulation, a cognitive control mechanism that supports both attention and memory by the suppression and enhancement of sensory processing in accordance with task goals. Using fMRI (functional magnetic resonance imaging), we show that healthy older adults demonstrated a prominent deficit in the suppression of cortical activity associated with task-irrelevant representations, whereas enhancement of taskrelevant activity was preserved. Moreover, this suppressionspecific attention deficit correlated with impaired working memory performance.

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تاریخ انتشار 2005